- 1 Pine Bark Extract
- 1.1 Pine Bark Extract in the Field of Research
- 1.2 Pine Bark Extract: Also has an Anti-inflammatory Effect on Gout
- 1.3 Purchase Pine Bark Extract
Pine Bark Extract
Pine bark extract is obtained from the bark of the French coastal pine (pinus pinaster). It contains a high level of antioxidative substances, micro nutrients and inflammation inhibitors. Ultimately, it is this combination of various active ingredients which makes it an interesting treatment for inflammatory diseases from the rheumatic field.
There are many very promising studies involving pine bark, especially with regards to osteoarthritis. A total of over 300 studies revealed no side-effects worth mentioning, making pine bark extract a very safe remedy that has been classified as a dietary supplement rather than a pharmaceutical product.
Pine Bark Extract in the Field of Research
STUDY INVOLVING 160 PARTICIPANTS: analgesic EFFECT
An Italian study group conducted the San Valentino osteoarthritis study as early as 2008. 1 It involved 77 patients who were administered a 100 mg daily dose of pine bark extract for a duration of 3 months. An additional 79 participants were part of the placebo group.
The pain symptoms were demonstrably reduced with pine bark extract, while the painless walking distance on the treadmill was increased by about 130 meters in three months. At the same time, the risk of suffering gastrointestinal problems was reduced by 63%.
Study Confirms Improved Mobility and Reduced Pain
The very same year, a Slovak group confirmed this study’s results. 2. One hundred patients suffering from mild to moderate osteoarthritis (degree I and II), received a daily dose of 150 mg for a duration of three months.
In contrast to a placebo group, the joint’s mobility increased in the treated group. In this case, the pain intensity was also significantly reduced. Consequently, participants who were supplied with pine bark extract were able to save more on painkillers at large.
But what could the effectiveness of pine bark extract be based on?
Inflammation inhibition proven in the blood
In 2008, Belcaro and colleagues set out to answer this question. The researchers examined the influence Pine Bark Extract has on marker proteins for inflammation and formation of radicals such as, for example, CRP.3 A clear decrease of CRP levels in the blood was observed in the group that was treated with pine bark extract.
Studies by Grimm et al.4 and also Schäfer et al.5 led to similar results: The taking of pine bark extract successfully reduced various inflammation markers, particularly including a 15% reduction of COX enzymes. Consequently, the deterioration of cartilage tissue was reduced by 25%.
As a result, pine bark extract appears to have a direct anti-inflammatory effect in the joints, whereby swelling and pains are reduced.
Pine Bark Extract: Also has an Anti-inflammatory Effect on Gout
Due to its anti-inflammatory effect, pine bark extract can also help in the treatment of inflammatory diseases stemming from the rheumatic field of disorders. A study by Peng and colleagues dealt with the influence the extract has on inflammation resulting from gout.6
The researchers examined the activation of inflammatory signaling pathways in cartilage cells, as well as their inhibition, by means of treatment with Pine Bark Extract in their rat model. While the uric acid crystals promote the release of inflammatory factors in the joints of the rats, pine bark extract very specifically inhibited the production of these substances.
The experiment demonstrated that, due to its anti-inflammatory properties, pine bark extract can also reduce the damage to joint cartilage that resulted from gout-like disorders.
Purchase Pine Bark Extract
Some good combination preparations for the joints also contain pine bark extract. Due to the fact, that the health of the joint cartilage depends on many factors, combination preparations are superior to individual active substances.
Studies on pine bark extract:
- Belcaro et al. 2008. Treatment of osteoarthritis with Pine Bark Extract. The SVOS (San Valentino Osteo-arthrosis Study, Evaluation of signs, symptoms, physical performance and vascular aspects. Phytother Res 22(4), 518-23; doi: 10.1002/ptr.2376 ↩
- Cisar et al. 2008. Effect of pine bark extract (Pine Bark Extract) on symptoms of knee osteoarthritis. Phytother Res 22(8), 1087-92; doi: 10.1002/ptr.2461 ↩
- Belcaro et al. 2008. Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pine Bark Extract. Redox Rep 13(6), 271-6; doi: 10.1179/135100008X309019 ↩
- Grimm T et al. Inhibition of NF-kB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract. J Inflamm 3: 1-15, 2006 ↩
- Schäfer A et al. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract. Biomed & Pharmacother 60: 5-9, 2006 ↩
- Peng et al. 2012. Pine Bark Extract attenuates the inflammatory and nitrosative stress on joint inflammation induced by urate crystals. Free Radic Biol Med 52(4), 765-74; doi: 10.1016/j.freeradbiomed.2011.12.003 ↩